Degrees and Certifications
- Postdoctoral Fellow in Biochemistry, St. Jude Children’s Research Hospital (2012)
- Ph.D. in Biochemistry and Molecular Biology, University of Georgia (2009)
- B.S. in Chemistry, B.A. in Economics, Clemson University (2004)
- CH 341 Biochemistry 1
- CH 342 Biochemistry 2
- CH 343 Biochemistry 1 Lab
- CH 344 Biochemistry 2 Lab
Research Interests & Grants
I study relationships between genome integrity and cellular lifespan. I am interested in understanding how chromatin modifying enzymes regulate gene expression and package the genome into molecular structures that promote faithful chromosome segregation during cell division, and how this process contributes to healthy ageing.
Errors in chromosome segregation can lead to cells receiving an improper complement of genetic material, and may cause cancer or other genetic disorders. Projects in my lab seek to characterize the roles of the histone deacetylase Sir2 in gene silencing, chromosome integrity and cellular lifespan using a simple eukaryotic model: yeast.
Publications and Presentations
2013 Sir2 is required for establishment of centromeric heterochromatin in fission yeast. Alper BJ, Job G, Yadav RK, Partridge JF. EMBO J.
2013 Evaluating amyloid beta 1-40 degradation by capillary electrophoresis. Alper BJ, Schmidt WK. Methods in Molecular Biology (in press)
2012 Centromeric heterochromatin assembly in fission yeast – balancing transcription, RNA interference and chromatin modification. Alper BJ*, Lowe BR*, Partridge JF. * Equal contribution. (Review.) Chromosome Research 20(5)521-34
2012 Cell-permeable, small molecule activators of the insulin-degrading enzyme. Kukday SS, Manandhar SP, Ludley MC, Burris ME, Alper BJ, Schmidt WK. J Biomolecular Screening,17(10):1348-1361
2012 The anion activation site of insulin degrading enzyme. Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, Rodgers DW. J Biological Chemistry 287(1):48-57
2009 Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes. Alper BJ, Rowse JW, Schmidt WK. Yeast 26(11):595-610
2009 A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro. Alper BJ, Schmidt WK. J Neuroscience Methods 178(1):40-45
2006 A common genetic system for functional studies of pitrilysin and related M16A proteases. Alper BJ, Nienow TE, Schmidt WK. Biochemical J 398(1):145-52